This 'why POCUS' manifesto is an absolute must-read for anyone who uses a stethoscope. “... In this manifesto, Dr. Istrail makes a solid case for why this technology should reboot the traditional heart and lung physical exam." - Eric Topol MD, author Deep Medicine ‘Why do we continue to guess what diseases reside within the chest when we can look inside and know for sure?’ asks internal medicine physician Dr. Larry Istrail in this poignant and persuasive manifesto. More than two centuries have passed since the 1816 inception of the stethoscope. During this time our medical care has advanced exponentially, while our physical exam has remained largely unchanged. That is until point-of-care ultrasound (POCUS) was brought to the patient’s bedside, enabling a clinician to digitally peel back the skin and observe the ecosystem of internal organs functioning in real-time. Through the lens of our physical exam origins, The POCUS Manifesto paints an inspiring landscape for the future of our physical exam and how POCUS plays a vital role in saving our patients from unnecessary complications, near-misses, and excess testing.